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health medicine and biotechnology
Bio-Magnetic Device To Enhance Mammalian Tissue Repair
Most magnetic therapy research and resulting devices have centered around pulsed unidirectional bioelectric systems. The technology available here for licensing utilizes a square-wave time-varying electrical current, which generates an electromagnetic field, via a wound coil incorporated into a sleeve and encircles the affected appendage. An external and commercially available time-varying compact electrical generator connects to the wound coil within the sleeve and is powered by a 9-volt battery.
Prior industry attempts to use electromagnetic therapy on mammalian tissue have historically applied higher than necessary levels of electromagnetism, typically at 50 gauss or more. Researchers found that by inducing a Fourier-curve, time-varying electromagnetic wave at levels within 0.05 0.5 gauss for a pre-determined time-period, was optimum to achieve successful mammalian tissue regeneration.
It is theorized that magnetic fields can alter the flow of positively charged calcium ions that interact with the muscles around small blood vessels causing them to relax. This effect in turn, causes constricted blood vessels to dilate, and dilated blood vessels to constrict. Depending upon the type of injury, enhanced tissue repair may occur through the suppression of inflammation, or the increase in blood flow.
health medicine and biotechnology
Ionic Magnetic Resonance Tailors Animal Cells/Tissues
The apparatus comprises a randomized gravity vector multiphasic culture system with a self-feeding growth module, an optionally disposable nutrient module, and a removable AIMR chamber that delivers a pulsating multivariant field to the contents of the culture system. It produces overlapping or fluctuating alternating ionic magnetic resonance frequencies at one or more modal intervals ranging from about 7.8 Hz to about 59.9 Hz to the cell chamber. The apparatus may yield better regulation that can be manipulated to allow for increased rate of cell growth, faster differentiation, increased cell fidelity, and the induction or suppression of selective physiological genes involved in directing cellular differentiation and dedifferentiation.
The use of an AIMR field may provide a significant improvement over existing bioreactors, including pulsating electromagnetic field (PEMF) and time-variance electromagnetic field (TVEMF) cellular growth induced systems, in that AIMR incorporates the modulation of cellular transcription. The AIMR system utilizes pre-sterilized disposable modules and a removable alternating ionic magnetic resonance chamber, reducing the hazard for contamination, allowing scientists to implement physiological and homeostatic parameters similar to a naturally occurring physiological system.